Protein Details: Short transient receptor potential channel 4

Protein ID

ICDB_Pro_1602

Protein Name

Short transient receptor potential channel 4

Gene Name

Trpc4; Trrp4

Organism

Mus musculus (Mouse)

Length

974 amino acids

AlphaFoldDB

AF-Q9QUQ5-F1-model_v4.pdb

Function

Sequence

MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISSFRFEVLGLLRGSKLSTIQSANAASSADSDEKSQSEGNGKDKRKNLSLFDLTTLIHPRSAAIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQNANQIFSVSEEITRQQAAGALERNIELESKGLASRGDRSIPGLNEQCVLVDHRERNTDTLGLQVGKRVCSTFKSEKVVVEDTVPIIPKEKHAHEEDSSIDYDLSPTDTAAHEDYVTTRL

PDB Structures

5Z96 6JZO 7CQP

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Abundantly expressed in brain (hippocampal CA1 pyramidal neurons; dentate gyrus granule cells; and cerebral cortical neurons; and in the septal nuclei and the mitral layer of olfactory bulb). Lower levels are detected in other tissues.

DOI ID

10.1074/jbc.m006635200; 10.1042/bj3110041; 10.1038/35055019; 10.1016/j.ceca.2008.11.002; 10.1002/jcp.22221; 10.3390/cells9030547

RefSeq

NP_001240611.1 [Q9QUQ5-2]; NP_058680.1 [Q9QUQ5-1]; XP_006501359.1 [Q9QUQ5-1];